But no one knew what they meant.
Now, researchers say they’ve finally uncovered a hidden molecular trigger that could explain rare cases of heart inflammation after mRNA COVID-19 shots—and the story is far more complicated, and unsettling, than anyone expected. Inside lab dishes and animal hearts, a pair of immune signals lit up like flar… Continues…
Scientists examining mRNA COVID-19 vaccines have zeroed in on two immune signaling proteins, CXCL10 and interferon-gamma, as possible drivers of the rare myocarditis cases seen mostly in young men. In experimental models, certain immune cells exposed to vaccine components began releasing these signals, setting off inflammatory cascades capable of affecting heart tissue. When researchers blocked those signals, markers of heart damage dropped, yet the broader protective immune response against the virus largely remained intact.
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